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CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 2
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DeCS
Descriptor
English
:
Cyclic Nucleotide Phosphodiesterases, Type 2
Descriptor
Spanish
:
Fosfodiesterasas de Nucleótidos Cíclicos Tipo 2
Descriptor
Portuguese
:
Nucleotídeo Cíclico Fosfodiesterase do Tipo 2
Tree Number:
D08.811.277.352.640.150.200
D08.811.277.352.640.155.200
D12.644.360.008.200
D12.644.360.009.200
D12.776.476.008.200
D12.776.476.009.200
Definition
English
:
A cyclic nucleotide phosphodiesterase subfamily that is activated by the binding of
CYCLIC GMP
to an allosteric domain found on the enzyme. Multiple enzyme variants of this subtype can be produced due to multiple alternative mRNA splicing. The subfamily is expressed in a broad variety of
tissues
and may play a
role
in mediating cross-talk between
CYCLIC GMP
and
CYCLIC CMP
pathways. Although the type 2
enzymes
are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), members of this class have additional specificity for
CYCLIC GMP.
History Note
English
:
2008(2000)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
52677
Unique Identifier:
D054678
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS